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The  limbic system and nearby structures
Regulation processes in an interpersonal lying experiment published in the journal of criminal psychology  their study emphasized that the social interaction between a deceiver and the deceived opponent is a determining factor for deception that involves emotions hence besides a great amount of cognitive control a successful lie also requires the regulation of emotions especially when deceiving somebody face to face their studies revealed that there was a decrease of alpha activity in left dorsolateral prefrontal cortex which predicted a higher frequency of deceptive responses as well as less guilt about deceiving the interrogator all these studies go to indicate that the selfish motive of lying has an effect on the limbic region of the neural systems and prolonged lying can even proceed to damage and desensitize it.
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